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KMID : 1189420100230020001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2010 Volume.23 No. 2 p.1 ~ p.12
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The Effects of Kami-bangpungtongseong-san Extracts on the Mouse Liver and Kidney Toxicated by Mercuric Chloride Subcutaneous Injection
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Yang Joon-Hyoung
Hong Seung-Ug
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Abstract
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Objective : For this study, mice on mercurial toxication were given mercuric subcutaneous injection to their abdomen factitiously. After delivering Kami- bangpungtongseong-san(KBT) extracts to the mice by oral administration, we observed changes from liver and kidney of mice.
Method : The BALB/c mice were distributed into three groups: No treated group(Normal group), Mercuric chloride subcutaneous injection group(Control group), Kami-bangpungtongseong-san-treated group (Sample group). KBT Extracts were delivered orally in 7 days. We observed involution of liver, necrosis of liver and cell plate loss of liver, lipid peroxidation CYP1A1 expression. We observed involution of proximal convoluted tubules, hypertrophy of Bowman’s capsule, periodic acid-Schiff(PAS)’s positive reaction of proximal convoluted tubules, heat shock protein(HSP 700’s positive reaction in glomerulus. For the charting the results, image analysis was taken. The result of image analysis was verified significance by Sigmaplot 2000(P<0.05).
Result : The mice’ liver on mercurial toxication were relieved involution of liver, necrosis of liver, and cell plate loss of liver and also declined lipid peroxidation and CYP1A1 expression. The mice’ kidney on mercurial toxication were relieved involution of proximal convoluted tubules, hypertrophy of Bowman’s capsule and increasing PAS’s positive reaction of proximal convoluted tubules. On the other hand it was declined HSP700’s positive reaction in glomerulus.
Conclusion : According to the result of study, we think that we can expect to the effect of KBT extracts’ therapeutic action to tissue injuries of the mice’ liver and kidney on acute mercurial toxication.
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KEYWORD
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Kamibangpungtongseong-san Extracts, Acute mercurial toxication, Liver, Kidney, Mercuric chloride
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